6533b833fe1ef96bd129b7f0

RESEARCH PRODUCT

The claustrum is a target for projections from the supramammillary nucleus in the rat.

Marie BarbierPierre-yves Risold

subject

0301 basic medicineSeptal RegionHypothalamus PosteriorTheta activityClaustrumHippocampal formation03 medical and health sciences0302 clinical medicineNeural PathwaysMemory formationAnimalsNeuronal Tract-TracersNeuronsbiologyGeneral NeuroscienceDentate gyrusClaustrumRatsNeuroanatomical Tract-Tracing Techniques030104 developmental biologynervous systembiology.proteinNeuroscience030217 neurology & neurosurgeryParvalbuminSupramammillary Nucleus

description

Injection of the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHAL) into the rat rostral and caudal supramammillary nucleus (SUM) provided expected patterns of projections into the hippocampus and the septal region. In addition, unexpectedly intense projections were observed into the claustrum defined by parvalbumin expression. Injections of the retrograde tracer fluorogold (FG) into the hippocampus and the region of the claustrum showed that the cells of origin of these projections distributed similarly within the borders of the SUM. The SUM is usually involved in control of hippocampal theta activity, but the observation of intense projections into the claustrum indicates that it may also influence isocortical processes. Therefore, the SUM may coordinate sensory processing in the isocortex with memory formation in the hippocampus.

yearjournalcountryeditionlanguage
2019-06-01Neuroscience
10.1016/j.neuroscience.2019.03.045https://pubmed.ncbi.nlm.nih.gov/30930128