6533b833fe1ef96bd129b883

RESEARCH PRODUCT

Marine Indole Alkaloids.

Natalie NetzTill Opatz

subject

540 Chemistry and allied sciencesAquatic Organismscarbolinesprenylated indolesmarine natural productsAntineoplastic AgentsReviewindolesalkaloidsbisindolesdiketopiperazinesIndole AlkaloidsBiological Factorslcsh:Biology (General)Anti-Infective Agents540 ChemieHumansnitrogen heterocycleslcsh:QH301-705.5

description

Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed.

10.3390/md13084814https://pubmed.ncbi.nlm.nih.gov/26287214