6533b833fe1ef96bd129c012
RESEARCH PRODUCT
Isoniazid cocrystallisation with dicarboxylic acids: vapochemical, mechanochemical and thermal methods
Liana OrolaInese SarcevicaArtis Konssubject
chemistry.chemical_classificationIsoniazid02 engineering and technologyGeneral Chemistry010402 general chemistry021001 nanoscience & nanotechnologyCondensed Matter Physics01 natural sciences0104 chemical sciencesSolventChain lengthDicarboxylic acidchemistryMelting pointmedicineOrganic chemistryGeneral Materials Science0210 nano-technologyEutectic systemThermal methodsmedicine.drugdescription
Cocrystallisation with a series of related compounds allows for the exploration of trends and limitations set by structural differences between these compounds. In this work, we investigate how the length of a dicarboxylic acid influences the outcome of cocrystallisation with isoniazid. We have performed a systematic study on the mechanochemical, thermal and solvent vapour-assisted cocrystallisation of aliphatic dicarboxylic acids (C3–C10) with isoniazid. Our results demonstrate that the rate of mechanochemical and vapour-assisted cocrystallisation depends on the acid chain length and shows alternation between odd- and even-chain acids. The results of thermal cocrystallisation showed that the eutectic melting temperatures of isoniazid–dicarboxylic acid mixtures follow the same trend as the melting points of dicarboxylic acids.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 | CrystEngComm |