ChemInform Abstract: (a)-Anellated Carbazoles with Antitumor Activity: Synthesis and Cytotoxicity.

6533b833fe1ef96bd129c0c3

RESEARCH PRODUCT

ChemInform Abstract: (a)-Anellated Carbazoles with Antitumor Activity: Synthesis and Cytotoxicity.

Ulf Pindur Dieter Schollmeyer G. Fischer M. Rogge

subject

Antitumor activity Human tumor Stereochemistry Cell culture Chemistry General Medicine Cytotoxicity K562 cells

description

The cycloadducts3,5, and7, readily available from methoxy-substituted 3-vinylindoles1 and2, were dehydrogenated withDDQ to the coplanar [a]-anellated carbazoles4,6, and8. Compound4a, also characterized by X-ray structural analysis, shows significant cytotoxicity against K562 und RXF393 human tumor cell lines.

year	journal	country	edition	language
2010-08-05	ChemInform

https://doi.org/10.1002/chin.199618125

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