6533b833fe1ef96bd129c2dc

RESEARCH PRODUCT

Biodegradable tablets having a matrix of low molecular weight poly-L-lactic acid and poly-D,L-lactic acid.

G. KöllerF. Moll

subject

Poly l lactic acidChemistryPolymersMatrix stabilityPolyestersPharmaceutical ScienceStereoisomerismDegree of polymerizationLactic acidMatrix (chemical analysis)Molecular WeightHydrolysischemistry.chemical_compoundDrug DiscoveryCopolymerLactatesMolar mass distributionOrganic chemistryLactic AcidBiotransformationTablets

description

Biodegradable Homo- and Copolymers of lactic and glycolic acids have been used for manufacture of microparticles and matrix implants1,5). To ensure sufficient hydrolytic matrix stability lactic acids of high and medium degree of polymerization have been used. The manufacture of poly lactic acid tablets with an average molecular weight of 25000 and 6000 was reported recently, after finishing the following study2). Bioabbaubare Gerusttabletten aus niedermolekularer poly-L-Milchsaure und poly-D,L-Milchsaure

10.1002/ardp.19903231015https://pubmed.ncbi.nlm.nih.gov/2080895