DNS reparācijas veicinātāja AV-153-Na mijiedarbība ar DNS

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DNS reparācijas veicinātāja AV-153-Na mijiedarbība ar DNS

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Daudzu savienojumu spēja tieši mijiedarboties ar DNS spirāli liecina par to mutagēnām un kancerogēnām īpašībām.Tomēr,pedējos gados, parādījās daudzi ziņojumi,par tiešo antimutagēnu mijiedarbību ar DNS,interkalējot un dažādveida piesaistoties DNS rievām. Nesen ir pieradīts, ka AV -153 ir antimutagēns un reparācijas veicinātājs. Darba mērķis bija izpētīt 1,4 dihidropiridīna atvasinājuma AV -153 mijiedarbību ar DNS ka arī parbaudīt AV-153 ietekmi uz DNS pasargāšanu no H2O2 iedarbības un DNS pārrāvumu reparāciju PA1 šūnās.Darbā izmantotas spektrofotometrijas un gēla elektroforēzes metodes, tajā skaitā vienšūnas gēla elektroforēzes metode.Tika pierādīts,ka AV – 153 mijiedarbojās ar DNS, bet tomēr nepasargā PA1 šūnas no ūdeņraža peroksīda iedarbības un neveicina PA1 šūnu reparāciju 1 nM koncentrācijā.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/15884

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