6533b833fe1ef96bd129c9ce

RESEARCH PRODUCT

Hypoxia, Lactate Accumulation, and Acidosis: Siblings or Accomplices Driving Tumor Progression and Resistance to Therapy?

Arnulf MayerPeter Vaupel

subject

Pathologymedicine.medical_specialtyHypoxic tumorTumor progressionmedicineCancer researchHypoxia (medical)medicine.symptomMalignant progressionBiologyTherapeutic resistanceStem cell phenotypeAcidosis

description

This chapter briefly summarizes the most important processes by which hypoxia, lactate accumulation, and acidosis may influence malignant progression and therapeutic resistance of solid malignant tumors. While these phenomena are often elements of an integrated reaction, they may occur independently of each other under certain circumstances. The latter information may be of interest with regard to possible “targeted” therapeutic interventions.

yearjournalcountryeditionlanguage
2013-01-01
https://doi.org/10.1007/978-1-4614-7411-1_28