6533b833fe1ef96bd129ca9b

RESEARCH PRODUCT

Metabolism and Lysine Biosynthesis Control in Brevibacterium Flavum: Impact of Stringent Response in Bacterial Cells

M. RuklishaR. JoninaG. PetrovicaL. Paegle

subject

Stringent responseLysineGuanosineMetabolismBiologycomplex mixturesCorynebacterium glutamicumchemistry.chemical_compoundchemistryBiochemistryBrevibacterium flavumbacteriaThreonineIntracellular

description

Parameters affecting lysine biosynthesis by Brevibacterium flavum RC 115 cells under stringent response conditions (test guanosine 5′-diphosphate 3′-diphosphate accumulation in cells) caused by threonine limitation were investigated. Experimental results confirmed that an increase in lysine biosynthesis by this bacterium under stringent response conditions might be a result of an increase in the intracellular concentration of NADPH as well as lysine export activity.

https://doi.org/10.1007/0-306-46888-3_3