6533b834fe1ef96bd129cb27
RESEARCH PRODUCT
Flow injection biamperometric determination of metronidazole with on-line photodegradation
J. Martínez CalatayudM. PalomequeJ. A. García BautistaJ. V. García Mateosubject
Flow injection analysisDetection limitCalibration curveAnalytical chemistrychemistry.chemical_elementIodineBiochemistryAnalytical ChemistrychemistryEnvironmental ChemistryPhotodegradationPlatinumQuantitative analysis (chemistry)SpectroscopyAntibacterial agentdescription
Abstract The determination of metronidazole is performed in a flow injection assembly, provided with a 40 W low pressure mercury lamp and a home-made biamperometric flow-cell furnished with two platinum electrodes polarized at 100 mV. The sample solution after being irradiated is inserted into a pure water stream. It then merges with an in situ mixed solution containing potassium iodide in sulphuric acid. The calibration graph was linear over the range 0.2–8.0 mg l −1 metronidazole; the 3 σ limit of detection was 0.008 mg l −1 ; the relative standard deviation was 0.6% (for 4 mg l −1 n = 13) and the sample throughput 50 h −1 . The influence of foreign compounds is slight and the method is applied for the determination of metronidazole in pharmaceutical and galenic formulations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-11-01 | Analytica Chimica Acta |