6533b834fe1ef96bd129cce9

RESEARCH PRODUCT

Reprogrammed induced pluripotent stem cells: how suitable could they be in reproductive medicine?

Carlos SimónAntonio PellicerRoberto Ensenat-waser

subject

Pluripotent Stem Cellsmedicine.medical_specialtySomatic cellReproductive medicineObstetrics and GynecologyBiologyPatient specificCellular ReprogrammingRegenerative MedicineModels BiologicalEmbryonic stem cellGermlineCell biologyReproductive MedicineImmunologymedicineHumansStem cellInduced pluripotent stem cellReprogramming

description

Human embryonic stem cells have the greatest potential for regenerative and reproductive medicine; unfortunately, their full application is limited by ethical and technical problems. In order to overcome these problems and get patient specific pluripotent cells from somatic cells, the field of reprogramming has moved to the generation of induced pluripotent stem cells by overexpression of four transcription factors after viral infection of the patient's somatic cells. In the present paper we review the limitations and milestones of this technique in both regenerative and reproductive medicine.

yearjournalcountryeditionlanguage
2008-09-26Fertility and Sterility
https://doi.org/10.1016/j.fertnstert.2008.12.034