Baktērijas Borrelia burgdorferi proteīna BBP28 strukturālie pētījumi

6533b834fe1ef96bd129d02e

RESEARCH PRODUCT

Baktērijas Borrelia burgdorferi proteīna BBP28 strukturālie pētījumi

Jēkabs Fridmanis

subject

BBP28 Borrelia burgdorferi Laima slimība Bioloģija kodolu magnētiskā rezonanse MALDI-TOF masspektrometrija

description

Laima slimība ir visizplatītākā ar vektoriem pārnēsātā slimība Amerikas Savienotajās Valstīs. Neraugoties uz tās plašo izplatību un smagajiem slimības simptomiem, pret to vēl aizvien nav pieejama vakcīna. Darba mērķis bija ekspresēt Laima slimības izraisītājas, baktērijas (Borrelia burgdorferi), ar membrānu saistīto lipoproteīnu BBP28 un noteikt tā struktūru. Izmantojot KMR datus, tika aprēķinātas divas BBP28 proteīna struktūras - viena pilna garuma un otra saīsinātai proteīna sekvencei, kas nesatur nestrukturēto 27 aa garo N gala segmentu. Strukturēto BBP28 daļu veido piecas α-spirāles un 14 aa gara virkne C-galā, kas kovalenti piesaistīta ar disulfīda saiti pie 4. un 5. α-spirāli savienojošās cilpas. Izmantojot MALDI-TOF masspektrometriju, tika noteikts, ka BBP28 varētu veidot nekovalenti saistītus oligomērus, tomēr KMR T1 un T2 relaksācijas laika mērījumi pierādīja, ka šķīdumā BBP28 atrodas monomēra formā. Darbs tika izstrādāts Latvijas Organiskās sintēzes institūtā no 2015. gada aprīļa līdz 2017. gada jūnijam.

year	journal	country	edition	language
2017-01-01

https://dspace.lu.lv/dspace/handle/7/35195

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
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  - PE2_6Nuclear, hadron and heavy ion physics
  - PE2_8Gas and plasma physics
  - PE2_5Classical and quantum physics of gravitational interactions
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  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
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  - PE2_16Non-linear physics
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SHSocial Sciences and Humanities
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