Beta-carbolines as benzodiazepine receptor ligands II: Synthesis and benzodiazepine receptor affinity of beta-carboline-3-carboxylic acid amides.

6533b834fe1ef96bd129d789

RESEARCH PRODUCT

Beta-carbolines as benzodiazepine receptor ligands II: Synthesis and benzodiazepine receptor affinity of beta-carboline-3-carboxylic acid amides.

Klaus P. Lippke Walter E. Müller Schunack Walter G Schunack Walter G

subject

Male Indoles Chemical Phenomena Stereochemistry medicine.drug_class Pharmaceutical Science In Vitro Techniques Ligands Mice Carboline-3-carboxylic acid medicine Animals Receptor chemistry.chemical_classification Brain Chemistry Benzodiazepine Receptors GABA-A Affinities Amino acid Chemistry Kinetics Membrane chemistry Amine gas treating Benzodiazepine receptor ligands Carbolines

description

Numerous beta-carboline-3-carboxamides were synthesized by amidation of beta-carboline-3-carboxylic acid, with various amino acids and amino acid esters serving as amine components, and tested in respect to their affinity for the benzodiazepine receptor in mouse brain membranes. The title compounds have affinities in the low micromolar range. The results are discussed with respect to their relevance for a possible beta-carboline structure containing the endogenous ligand of the benzodiazepine receptor.

year	journal	country	edition	language
1985-06-01	Journal of pharmaceutical sciences

10.1002/jps.2600740620 https://pubmed.ncbi.nlm.nih.gov/2991493

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