6533b834fe1ef96bd129e2fe

RESEARCH PRODUCT

Ionic Hydrogel Based on Chitosan Cross-Linked with 6-Phosphogluconic Trisodium Salt as a Drug Delivery System.

Virginia MerinoMayte Martínez-martínezMayte Martínez-martínezGuillermo Rodríguez-bernaMarta González-álvarezMª Jesús HernándezAvelino CormaIsabel González-álvarezMarival Bermejo

subject

Polymers and PlasticsPolymersAdministration TopicalIonic bondingSalt (chemistry)Bioengineering02 engineering and technology010402 general chemistry01 natural sciencesGluconatesHydrogel Polyethylene Glycol DimethacrylateBiomaterialsChitosanchemistry.chemical_compoundQUIMICA ORGANICADrug Delivery SystemsMaterials ChemistryHumanschemistry.chemical_classificationChitosanWound HealingAqueous solutionWound Closure TechniquesSodiumCationic polymerization021001 nanoscience & nanotechnology0104 chemical sciencesDrug vehicleKineticsCross-Linking ReagentsChemical engineeringchemistrySelf-healing hydrogelsDrug delivery0210 nano-technology

description

[EN] In this work, 6-phosphogluconic trisodium salt (6-PG(-)Na(+)) is introduced as a new aqueous and nontoxic cross-linking agent to obtain ionic hydrogels. Here, it is shown the formation of hydrogels based on chitosan cross-linked with 6-PG(-)Na(+). This formulation is obtained by ionic interaction of cationic groups of polymer with anionic groups of the cross linker. These hydrogels are nontoxic, do not cause dermal irritation, are easy to extend, and have an adequate adhesion force to be applied as polymeric film over the skin. This AWN formulation exhibits a first order release kinetic and can be applied as drug vehicle for topical administration or as wound dressing for wound healing. The primary goal of this communication is to report the identification and utility of 6-phosphogluconic trisodium salt (6-PG(-)Na(+)) as a nontoxic cross-linker applicable for cationic polymers.

yearjournalcountryeditionlanguage
2018-04-01Biomacromolecules
10.1021/acs.biomac.8b00108https://pubmed.ncbi.nlm.nih.gov/29537830