6533b834fe1ef96bd129e2ff

RESEARCH PRODUCT

Binucleate cells in the Ehrlich ascites tumor. Autoradiographic labeling

José PertusaJosé A. PellicerVicente Alcober

subject

Cell NucleusPathologymedicine.medical_specialtyBinucleated cellsMice Inbred StrainsCell BiologyGeneral MedicineCompartment (chemistry)BiologyTritiumEhrlich ascitesMiceBiochemistryMitotic IndexmedicineAnimalsAutoradiographyFemaleFluorouracilCarcinoma Ehrlich TumorMitosisAfter treatmentThymidine

description

Abstract An autoradiographic study was performed on binucleate and mitotic cells in the Ehrlich ascites tumor (EAT) untreated and after treatment with 5-fluorouracil (FU). The number of binucleate cells was greater in the treated tumor than in the controls. It was also observed that the number of labeled mitoses was greater in the Fu-treated tumor. Autoradiographic labeling showed that the cells that proved to be binucleate had previously passed through S-phase; thus, these cells belonged to the proliferative compartment.

yearjournalcountryeditionlanguage
1989-01-01Biology of the Cell
https://doi.org/10.1111/j.1768-322x.1989.tb00773.x