Pretaudzēju protekcija ar žurkas TERT apgrieztās transkriptāzes domēnu DNS imunizētās pelēs

6533b834fe1ef96bd129e562

RESEARCH PRODUCT

Pretaudzēju protekcija ar žurkas TERT apgrieztās transkriptāzes domēnu DNS imunizētās pelēs

Alisa Kurļanda

subject

TERT RT-TERT domēns Bioloģija audzējs bioluminiscences attēlveidošana DNS vakcīna

description

Darbā tika pārbaudītas un novērtētas žurkas TERT un RT-TERTin DNS imunogēno konstrukciju pretaudzēju protektīvās īpašības pret ar luciferāzi iezīmētām 4T1 derivātu adenokarcinomas līniju šūnām peļu modelī. Audzēju attīstības, atgrūšanās vai augšanas novērošanā tika veikta imunizētiem dzīvniekiem ar in vivo bioluminiscences attēlveidošanu. Iegūtie in vivo bioluminiscences dati liecina par ar RT-TERTin efektīvāku dzīvnieku aizsardzību no audzējiem nekā ar pilna garuma aktīvo TERT. Ar plūsmas citometriju tika pārbaudīta pret TERT vērsto T-šūnas atbildes reakcija. Darba pārbaudītie TERT DNS imunogēni spēj izrāsit specifisko T-šūnas atbildi. Tika noteikts, ka stimulācija ar TERT sekvencei atbilstošiem oligopeptīdiem izraisa imunizēto dzīvnieku Th un CTL limfocītu aktivāciju. Daļa no darba rezultātiem tika publicēta 2020. gadā 18.junija žurnālā “Vaccines” rakstā ar nosaukumu “Telomerāzes reversās transkriptāzes domēna ekspresija inducē lītisko šūnu reakciju ar DNS imunizētām pelēm un ierobežo peles adenokarcinomas 4T1 šūnu tumorigēno un metastātisko potenciālu”.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54514

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