Adenozīna A3 receptora L248i pozīcijas funkcionālā izpēte

6533b835fe1ef96bd129eef4

RESEARCH PRODUCT

Adenozīna A3 receptora L248i pozīcijas funkcionālā izpēte

Toms Bartulsons

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Adenozīna A3 receptors pieder ar G – proteīnu saistīto receptoru grupai, kurai ir liela nozīme fizioloģiskajās funkcijās un ir daudzu farmakoloģisko pētījumu mērķis. Šis ir pirmais pētījums, kurā salīdzina adenozīna A3 receptora wild type un cilvēku populācijā sastopamā receptora mutanta aktivitāti. Darbā ir veikta pētāmā receptora kodējošās sekvences maiņa un sajūgšana ar zaļi fluorescējošo proteīnu. Darbā tika noskaidrota polimorfisma ietekme uz receptora aktivitāti. Tāpat noskaidrots, ka GFP nav piemērots adenozīna A3 lokalizācijas pētījumiem. Darba mērķis ir adenozīna A3 receptora cilvēka populācijā sastopamā nesinonīmā SNP rs35511654 ietekmes uz receptora aktivitāti un receptora lokalizāciju noteikšana. Darbs veikts no 2012. gada oktobra līdz 2013. gada maijam Latvijas Biomedicīnas pētījumu un studiju centrā.Atslēgas vārdi: Adora3, PCR virzītā mutaģenēze, I248L, rs35511654, GFP.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/18942

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