6533b835fe1ef96bd129f2fc

RESEARCH PRODUCT

Solid–liquid extraction of ω-amino acids using ditopic receptors

Sergio PeransiGemma M. Rodríguez-muñizAna M. CosteroSalvador GilPablo Gaviña

subject

chemistry.chemical_classificationCation bindingChemistryOrganic ChemistryExtraction (chemistry)BiochemistryIonAmino acidchemistry.chemical_compoundThioureaAmideDrug DiscoveryPolymer chemistryProton NMROrganic chemistrySolid phase extraction

description

Abstract Five heteroditopic ligands have been prepared to be used in solid–liquid extraction of ω-amino acids into DMSO solutions. The prepared ligands contain crown ethers as cation binding sites and thiourea or amide groups for anion recognition. The aliphatic zone of the 1H NMR spectra suggests that two different species related to the amino acid are present in solution. One of these species is the complexed zwitterionic form and the other seems to be free non-zwitterionic amino acid. The presence of these two species allows extraction efficiencies higher than 100%.

yearjournalcountryeditionlanguage
2008-01-01Tetrahedron
https://doi.org/10.1016/j.tet.2007.10.066