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RESEARCH PRODUCT
Two New Acylated Tridesmosidic Saponins from Astragalus armatus
Miyamoto TomofumiNabil SemmarMarie Aleth Lacaille-duboisYassine Mrabetsubject
chemistry.chemical_classificationTraditional medicineOrganic ChemistryGlycosideFabaceaeAstragalus armatusBiochemistryCatalysisInorganic Chemistrychemistry.chemical_compoundchemistryDrug DiscoveryCycloastragenolPhysical and Theoretical Chemistrydescription
Two new tridesmosidic glycosides of (3β,6α,16β,20R,24S)-20,24-epoxycycloartane-3,6,16,25-tetrol (=cycloastragenol), armatosides I and II (1 and 2, resp.), were isolated from the roots of Astragalus armatus (Fabaceae) as well as the known bidesmosidic glycosides of cycloastragenol, trigonoside II (3) and trojanoside H (4). Their structures were elucidated as (3β,6α,16β,20R,24S)-3-O-(2,3-di-O-acetyl-β-D-xylopyranosyl)-20,24-epoxy-25-O-β-D-glucopyranosyl-6-O-β-D-xylopyranosylcycloartane-3,6,16,25-tetrol (1), and (3β,6α,16β,20R,24S)-3-O-(2-O-acetyl-β-D-xylopyranosyl)-20,24-epoxy-25-O-β-D-glucopyranosyl-6-O-β-D-xylopyranosylcycloartane-3,6,16,25-tetrol (2). These structures were established by extensive NMR and MS analyses and by comparison with literature data.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-01 | Helvetica Chimica Acta |