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RESEARCH PRODUCT
ChemInform Abstract: Organocatalytic Enantioselective Aza-Friedel-Crafts Reaction of 2-Naphthols with Benzoxathiazine 2,2-Dioxides.
Marc Montesinos-magranerCarlos VilaJosé R. PedroIsabel FernándezM. Carmen MuñozRuben CantonGonzalo Blaysubject
chemistry.chemical_compoundNucleophileChemistryOrganocatalysisEnantioselective synthesisOrganic chemistryGeneral MedicineSesamolFriedel–Crafts reactionBifunctional catalystdescription
An organocatalytic enantioselective aza-Friedel–Crafts addition of 2-naphthols to benzoxathiazine 2,2-dioxides is described using a quinine-derived bifunctional catalyst. The method allows the use of a wide range of aromatic compounds as nucleophiles, including 1-naphthol and sesamol, and benzoxathiazines 2,2-dioxides, expanding the existing state of the art enantioselective synthesis of aminomethylnaphthol derivatives.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-11-19 | ChemInform |