6533b835fe1ef96bd129f5de

RESEARCH PRODUCT

Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery

Philipp SchippersStefan TenzerAxel MethnerBruno SeitajRita La RovereVerena WüllnerLi ZhangUte DistlerChristina WolfGeert BultynckFelicia MaullJan B. Parys

subject

Programmed cell deathmitochondrial metabolismProtein familyApoptosisMitochondrioncell survivalArticleGHITMMitochondrial ProteinsTMBIMHumansInner mitochondrial membranelcsh:QH301-705.5bcl-2-Associated X ProteinBAX inhibitor 1ChemistryMembrane ProteinsGeneral MedicineTransmembrane proteinCell biologyDNA-Binding Proteinsmitochondriacell deathMitochondrial biogenesislcsh:Biology (General)Mitochondrial Membranes

description

The Transmembrane Bax Inhibitor-1 motif (TMBIM)-containing protein family is evolutionarily conserved and has been implicated in cell death susceptibility. The only member with a mitochondrial localization is TMBIM5 (also known as GHITM or MICS1), which affects cristae organization and associates with the Parkinson&rsquo

yearjournalcountryeditionlanguage
2020-09-01
10.3390/cells9102147https://lirias.kuleuven.be/handle/123456789/661458