6533b835fe1ef96bd129fb0d

RESEARCH PRODUCT

Depletion of

Benítez-páez AlfonsoGómez Del Pugar Eva MLópez-almela InmaculadaMoya-pérez ÁNgelaCodoñer-franch PilarSanz Yolanda

subject

obesitygut microbiotapermubiomeBlautia wexleraeHost-Microbe Biologychildrenprobioticsinflammationinsulin resistancePBMCsmicrobiotagut inflammationchildhood obesityBlautia lutiResearch Article

description

Child obesity constitutes a risk factor for developing insulin resistance which, if sustained, could lead to more severe conditions like type 2 diabetes (T2D) in adulthood. Our study identified previously unknown species whose depletion (Blautia luti and Blautia wexlerae) is associated with insulin resistance in obese individuals. Our results also indicate that these bacterial species might help to reduce inflammation causally linked to obesity-related complications. Childhood is considered a window of opportunity to tackle obesity. These new findings provide, therefore, valuable information for the future design of microbiota-based strategies for the early prevention of obesity-related complications.

yearjournalcountryeditionlanguage
2020-03-27mSystems
10.1128/msystems.00857-19https://pubmed.ncbi.nlm.nih.gov/32209719