6533b835fe1ef96bd129fd03
RESEARCH PRODUCT
Molybdenum Pentachloride Mediated Synthesis of Spirocyclic Compounds by Intramolecular Oxidative Coupling
Roland FröhlichGregor SchnakenburgSiegfried R. WaldvogelKathrin WehmingDieter SchollmeyerAnton KehlMoritz SchubertMartin Niegersubject
010405 organic chemistryStereochemistryOrganic Chemistrychemistry.chemical_elementMolybdenum pentachloride010402 general chemistry01 natural sciences0104 chemical sciencesScholl reactionchemistryMolybdenumIntramolecular forceMoietyCinnamatesOxidative coupling of methanePhysical and Theoretical ChemistryPhenanthrenesdescription
The oxidative treatment of (m)ethyl 2-aryl cinnamates equipped with methoxy groups in position 4 of the phenyl moiety promote the formation of cyclohexadienone substructures. This dealkylative oxidative C–C coupling gives access to spirocyclic compounds and avoids the construction of the corresponding phenanthrenes. Furthermore, the transformation can be expanded to other spirocyclic systems.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-12-07 | European Journal of Organic Chemistry |