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RESEARCH PRODUCT
Synthesis and Anti-Tumor Activity of Novel Aminomethylated Derivatives of Isoliquiritigenin
Thomas EfferthWang XiqingHan YingzhiFu HaoranYu-hang ZhangYu-jie FuXiao Pengsubject
Magnetic Resonance SpectroscopyPharmaceutical ScienceAntineoplastic AgentsArticleAnalytical Chemistrylcsh:QD241-441MiceStructure-Activity Relationshipchemistry.chemical_compoundChalconeslcsh:Organic chemistryIn vivoCell Line TumorDrug DiscoveryMannich reactionAnimalsHumansStructure–activity relationshipCytotoxic T cellPhysical and Theoretical ChemistryMannich reactionCell ProliferationMice Inbred BALB COrganic Chemistryorganic synthesisIn vitrochemistryBiochemistryChemistry (miscellaneous)Cell cultureaminomethylated derivatives of isoliquiritigeninMCF-7 CellsMolecular MedicineFemaleOrganic synthesisanti-tumor activityDrug Screening Assays AntitumorIsoliquiritigenindescription
A series of new aminomethylated derivatives of isoliquiritigenin was synthesized. The structures of the compounds were confirmed by IR, MS, NMR, 13C-NMR and elemental analyses. Cytotoxic activities of these derivatives towards the human prostatic cell line PC-3, human mammary cancer cell line MCF-7 and human oophoroma cell line HO-8910 in vitro were tested. The IC50 values showed cytotoxic activities of some of these new derivatives were relatively strong. Furthermore, tumor growth inhibition in vivo of aminomethylated derivatives of isoliquiritigenin 15 was superior to that of isoliquritigenin and reached inhibition rates of 71.68%. The detailed synthesis, spectroscopic data, biological and pharmacologicalactivities of the synthesized compounds were provided.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-10-31 | Molecules |