6533b835fe1ef96bd12a0152

RESEARCH PRODUCT

Development of a Multifunctional Bioerodible Nanocomposite Containing Metronidazole and Curcumin to Apply on L-PRF Clot to Promote Tissue Regeneration in Dentistry

Fabio D'agostinoGiuseppina CampisiFrancesco Carfì PaviaGiuseppe AngellottiMarco ContardiAlice ConigliaroViviana De CaroRodolfo MauceriDenise MurgiaRiccardo Alessandro

subject

Sonicationnanostructured lipid carriersMedicine (miscellaneous)02 engineering and technologynanostructured lipid carrier030226 pharmacology & pharmacyhydrophilic spongeGeneral Biochemistry Genetics and Molecular BiologyArticle03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemetronidazolebone regenerationSettore MED/28 - Malattie OdontostomatologicheHyaluronic acidhyaluronic acidZeta potentialcurcuminBone regenerationlcsh:QH301-705.5Dental alveolustooth extractionNanocompositenanocompositeChemistryRegeneration (biology)hyaluronic acid.L-PRFBuccal administration021001 nanoscience & nanotechnologylcsh:Biology (General)Settore CHIM/09 - Farmaceutico Tecnologico Applicativo0210 nano-technologyBiomedical engineering

description

Teeth extractions are often followed by alveolar bone reabsorption, although an adequate level of bone is required for reliable rehabilitations by dental implants. Leukocyte and platelet-rich fibrin (L-PRF) has been widely applied in regenerative procedures and with antibiotic and antioxidant agents could play an essential role in hard and soft tissue healing. In this work, a nanocomposite (Sponge-C-MTR) consisting of a hyaluronate-based sponge loaded with metronidazole (MTR) and nanostructured lipid carriers containing curcumin (CUR-NLC) was designed to be wrapped in the L-PRF&trade

yearjournalcountryeditionlanguage
2020-10-16Biomedicines
10.3390/biomedicines8100425https://www.mdpi.com/2227-9059/8/10/425