Vaskulārā miRoma raksturojums un tā saistība ar koronāro artēriju slimību

6533b836fe1ef96bd12a03f9

RESEARCH PRODUCT

Vaskulārā miRoma raksturojums un tā saistība ar koronāro artēriju slimību

Katrīna Daila Neiburga

subject

bioinformātikas analīze miRNS ekspresija koronāro artēriju slimība Bioloģija asinsvadu sieniņu audi

description

Koronāro artēriju slimības ir viens no vadošajiem mirstības cēloņiem daudzās pasaules valstīs. Lai gan genomā ir atrasti vairāki simti riska lokusi, liela daļa no tiem atrodas proteīnus nekodējošā genoma daļā, tāpēc ir grūti aprakstīt to funkcionālo nozīmi. Lai to risinātu, var izmantot milti-omikas pieejas, apvienojot datus no dažādiem molekulārās regulācijas līmeņiem. Šajā darbā tiek aprakstīta iekšējās mammārās artērijas miRNS kopa labi raksturotai pacientu kohortai, kam veikta koronāro artēriju šuntēšana ar nolūku šos datus apvienot ar genoma un proteoma analīzi šajos pašos audos. Tāpat tiek parādītas vairākas miRNS asociācijas ar zināmiem koronāro artēriju slimības riska faktoriem, aprakstīts kohortā esošas pacientu apakšgrupas, izmantojot hierarhisko klāsterēšanu un identificēti diferenciāli ekspresēti miRNS šajos pacientos.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54486

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