dsRNS imūnmodulatoro īpašību izpēte ex vivo

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RESEARCH PRODUCT

dsRNS imūnmodulatoro īpašību izpēte ex vivo

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Dubultspiralizēta RNS (dsRNS) ir patogēnu asociēta molekulārā struktūra, kas darbojas kā iedzimtās un adaptīvās imūnatbildes aktivators. Larifans ir farmaceitisks produkts, kas satur dažāda garuma dabīgas izcelsmes dsRNS molekulas. Maģistra darba mērķis bija raksturot Larifana ietekmi uz imunoloģiski nozīmīgiem parametriem ex vivo kultivētiem limfocītiem. Ar Luminex xMAP tehnoloģiju tika raksturota Larifana ietekme uz 29 dažādu citokīnu un hemokīnu produkciju un ar plūsmas citometriju 18 dažādu limfocītu marķieru ekspresijas izmaiņas. Larifans stimulēja antigēnprezentējošām šūnām raksturīgu un šūnu mediēto imūnatbildi veicinošu citokīnu, kā arī hemokīnu ar tiešām antivirālām īpašībām produkciju. Larifans stimulēja aktivācijas marķieru ekspresiju T un B limfocītu un NK šūnu subpopulācijās.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/18926

PEPhysical Sciences and Engineering
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