6533b836fe1ef96bd12a1195

RESEARCH PRODUCT

Synthetic studies toward natural furanosesquiterpenoids from santonin. Synthesis of (+)-1,2-dihydrotubipofuran

Begoña GarcíaLuz CardonaJosé R. PedroDesamparados Ruiz

subject

chemistry.chemical_compoundBicyclic moleculeChemistryStereochemistryOrganic ChemistryDrug DiscoveryEnantiomerSesquiterpeneBiochemistrySantonin

description

Abstract Santonin (1) was converted into (+)-1,2-dihydrotubipofuran (13) via a synthetic pathway involving a very easy preparation of 7,11-ene-8,12-olide and 8,12-furan moieties and A-ring elaboration on the eudesmane framework.

https://doi.org/10.1016/s0040-4020(01)80707-9