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RESEARCH PRODUCT
Radioactively labelled epoxides. Part VI. tritium-labelled mono- and dimethyl substituted phenyl oxiranes (styrene oxides)
Frans SetiabudiKarl L. PlattFranz Oeschsubject
ChemistryOrganic ChemistryBiochemistryAnalytical ChemistryStyreneGlutathione transferasechemistry.chemical_compoundDrug DiscoveryOrganic chemistryRadiology Nuclear Medicine and imagingTritiumEpoxide hydrolaseSpectroscopySodium borotritidedescription
Tritium-labelled (E)- and (Z)-2,3-dimethyl-2-phenyl oxirane 4, (E)- and (Z)-2-methyl-3-phenyl oxirane 7 and 2,2-dimethyl-3-phenyl oxirane 11 have been prepared by reduction of the corresponding bromoketones with sodium borotritide to the corresponding bromohydrins followed by cyclization to the oxiranes. These oxiranes were successfully used as diagnostic substrates to distinguish between different forms of epoxide hydrolase and glutathione transferase.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-11-01 | Journal of Labelled Compounds and Radiopharmaceuticals |