6533b836fe1ef96bd12a13c0

RESEARCH PRODUCT

Influence of anti-inflammatory flavonoids on degranulation and arachidonic acid release in rat neutrophils.

María TorderaMaría Luisa FerrándizMaría José Alcaraz

subject

NaringeninNeutrophilsAmentoflavoneBiologyGeneral Biochemistry Genetics and Molecular Biologychemistry.chemical_compoundStructure-Activity RelationshipAnimalsheterocyclic compoundsChrysinGlucuronidaseFlavonoidsArachidonic AcidMolecular StructureAnti-Inflammatory Agents Non-Steroidalfood and beveragesRatsN-Formylmethionine Leucyl-PhenylalaninechemistryBiochemistryApigeninRegression AnalysisArachidonic acidMuramidaseKaempferolLysosomesLuteolinFisetin

description

We assessed the effects of 24 flavonoid derivatives, reported as anti-inflammatory, on lysosomal enzyme secretion and arachidonic acid release in rat neutrophils. Amentoflavone, quercetagetin- 7-O -glucoside, apigenin, fisetin, kaem pferol, luteolin and quercetin were the most potent inhibitors of β-glucuronidase and lysozyme release. The first com pound was also able to inhibit basal release. These flavonoids besides chrysin and to a reduced extent, naringenin, significantly inhibited arachidonic acid release from membranes. A correlation between degranulation and arachidonic acid release was found for this series of compounds. Structureactivity relationships and implications for the anti-inflammatory effects of these flavonoids were discussed

yearjournalcountryeditionlanguage
1994-04-01Zeitschrift fur Naturforschung. C, Journal of biosciences
10.1515/znc-1994-3-412https://pubmed.ncbi.nlm.nih.gov/8018254