6533b836fe1ef96bd12a1515
RESEARCH PRODUCT
Prion protein gene frequencies in three Sicilian dairy sheep populations
Fabrizio VitaleB. PortolanoRaffaella FinocchiaroJohannes B.c.h.m. Van KaamSanto CaracappaFrancesco PinelliMaria VitalePascal A. OltenacuMarina Scimonellisubject
GeneticsPrPsheep040301 veterinary sciencesHaplotype frequency Prion protein Scrapie Sheep.Haplotype0402 animal and dairy scienceOutbreakScrapie04 agricultural and veterinary sciencesBiology040201 dairy & animal science0403 veterinary scienceSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoValineGenotypeAnimal Science and ZoologyfrequencieFlocklcsh:Animal culturePrion proteinGenelcsh:SF1-1100description
The objective of this paper was to investigate the prion protein (PrP) genotype and haplotype frequencies in three Sicilian dairy sheep populations. The three populations were: (1) 1096 Valle del Belice animals, (2) 1143 Comisana animals, and (3) 1771 individuals from 5 flocks with scrapie outbreaks, in which the animals were crossbreds derived from indigenous Sicilian dairy breeds. PrP genotypes are described for the three codons 136 (Alanine or Valine; A, V), 154 (Histidine or Arginine; H, R), and 171 (Glutamine, Arginine or Histidine; Q, R, H) which represent polymorphisms known to be linked with scrapie susceptibility. The Valle del Belice haplotype frequencies were 32.3% ARR, 6.5% AHQ, 1.0% ARH, 58.8% ARQ, and 1.4% VRQ. The Comisana frequencies were 39.4% ARR, 2.9% AHQ, 2.9% ARH, 50.9% ARQ, and 3.9% VRQ. In the flocks with scrapie outbreaks the frequencies were 32.8% ARR, 2.4% AHQ, 1.7% ARH, 59.1% ARQ, and 3.9% VRQ. In all three populations ARQ and ARR were the most frequent haplotypes. Multiple generations of strong selection will be needed to fixate the most resistant ARR haplotype.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-01 |