6533b836fe1ef96bd12a15c2
RESEARCH PRODUCT
Transition-Metal-Free Decarboxylative Photoredox Coupling of Carboxylic Acids and Alcohols with Aromatic Nitriles.
Benjamin LippAlexander M. NauthTill Opatzsubject
Coupling (electronics)chemistry.chemical_compoundTransition metalchemistry010405 organic chemistryOrganic ChemistryOrganic chemistryBond formation010402 general chemistryPhotochemistry01 natural sciencesOxalate0104 chemical sciencesdescription
A transition-metal-free protocol for the redox-neutral light-induced decarboxylative coupling of carboxylic acids with (hetero)aromatic nitriles at ambient temperature is presented. A broad scope of acids and nitriles is accepted, and alcohols can be coupled in a similar fashion through their oxalate half esters. Various inexpensive sources of UV light and even sunlight can be used to achieve this C–C bond formation proceeding through a free radical mechanism.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-07-25 | The Journal of organic chemistry |