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RESEARCH PRODUCT

New Insight into Immunity and Immunopathology of Rickettsial Diseases

Giustina VitaleDavid H. WalkerSalvatore Di RosaAntonio CascioGiovam Battista RiniEnrico CillariIlenia PepeAntonio CarroccioAurelio SeiditaPasquale Mansueto

subject

lcsh:Immunologic diseases. AllergySettore MED/09 - Medicina InternaVirulence FactorsRickettsial diseasesImmunologyRickettsiaceae InfectionsVirulenceImmunopathologyReview ArticleAdaptive ImmunityHost SpecificityMicrobiologyImmune systemBacterial ProteinsImmunityAnimalsHumansImmunology and AllergyAnaplasmaMolecular Targeted TherapyRickettsiaArthropodsPathogenRickettsieaeGeneticsImmunopathology; Rickettsial diseasesbiologyEffectorGeneral Medicinebacterial infections and mycosesbiology.organism_classificationAcquired immune systemOrientiaImmunity InnateGene Expression RegulationHost-Pathogen Interactionslcsh:RC581-607Signal Transduction

description

Human rickettsial diseases comprise a variety of clinical entities caused by microorganisms belonging to the generaRickettsia,Orientia,Ehrlichia, andAnaplasma. These microorganisms are characterized by a strictly intracellular location which has, for long, impaired their detailed study. In this paper, the critical steps taken by these microorganisms to play their pathogenic roles are discussed in detail on the basis of recent advances in our understanding of molecularRickettsia-host interactions, preferential target cells, virulence mechanisms, three-dimensional structures of bacteria effector proteins, upstream signalling pathways and signal transduction systems, and modulation of gene expression. The roles of innate and adaptive immune responses are discussed, and potential new targets for therapies to block host-pathogen interactions and pathogen virulence mechanisms are considered.

yearjournalcountryeditionlanguage
2011-09-01Clinical and Developmental Immunology
https://doi.org/10.1155/2012/967852