6533b836fe1ef96bd12a1b79
RESEARCH PRODUCT
Neurosteroids in the Retina
D RussoG GalizziFederico PiccoliStefania D'agostinoR. GuarneriM GuarneriG. DragoCaterina CascioP. GuarneriG. De Leosubject
RetinaRetinal DisorderNeuroactive steroidGeneral NeuroscienceLong-term potentiationRetinalBiologyNeuroprotectionGeneral Biochemistry Genetics and Molecular Biologychemistry.chemical_compoundmedicine.anatomical_structureHistory and Philosophy of SciencechemistrymedicinePregnenolone sulfateNeuroscienceHormonedescription
Steroids may have a powerful role in neuronal degeneration. Recent research has revealed that steroids may influence the onset and progression of some retinal disorders as well as neurodegenerative diseases and, as in brain, they accumulate in the retina via a local synthesis (neurosteroids) and metabolism of blood-circulating steroid hormones. Their crucial role as neurodegenerative and neuroprotective agents has been also upheld in a retinal excitotoxic paradigm. These findings are reviewed especially from the emerging perspective that after an insult local changes in steroidogenic responses and consequent neurosteroid availability might turn out to be offensive or defensive cellular adaptations for the potentiation or prevention of neuronal death.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-12-01 | Annals of the New York Academy of Sciences |