6533b836fe1ef96bd12a1bc4

RESEARCH PRODUCT

ChemInform Abstract: Palladium-Catalyzed Synthesis of Mono- and Diphosphorylated 1,10-Phenanthrolines.

Alexandre MitrofanovAlexandre MitrofanovAlla Bessmertnykh LemeuneIrina P. BeletskayaIrina P. BeletskayaChristine SternRoger GuilardN. S. GulyukinaN. S. Gulyukina

subject

chemistry.chemical_classificationchemistry.chemical_compoundBase (chemistry)chemistryOrganic chemistrychemistry.chemical_elementGeneral MedicineMedicinal chemistryTriethylamineCatalysisPalladium

description

A general protocol for the coupling of mono- and dihalo-1,10-phenanthrolines with diethyl phosphite is reported. This reaction proceeds smoothly in the presence of a Pd(OAc)2/dppf catalytic system and triethylamine as a base.

https://doi.org/10.1002/chin.201318132