6533b836fe1ef96bd12a1be4

RESEARCH PRODUCT

syn-1,6-imino-8,13-oxido[14]annulene

J. Alberto MarcoEmanuel VogelJohann LexJuan F. SanzHans SchmicklerBarbara Schwartzkopff-fischer

subject

Hydrogen bondChemistryStereochemistryOrganic ChemistryDrug DiscoveryAnnuleneBiochemistryMedicinal chemistry

description

Abstract syn -1,6-Imino-8,13-oxido[14]annulene (1) , an aromatic annulene featuring closely spaced NH and O-bridges, has been synthesized. Contrary to expectation, NH ⋯ O hydrogen bonding in I does not profit from the proximity of the functionalities noticeably.

https://doi.org/10.1016/s0040-4039(00)94413-7