6533b836fe1ef96bd12a1c19
RESEARCH PRODUCT
�ber die positiv inotrope Wirkung von Dibutyryl-3?,5?-AMP an isolierten Rattenvorh�fen
H. ScholzHermann NawrathThomas Meinertzsubject
Inotropemedicine.medical_specialtyPhysiologyChemistryClinical BiochemistryCardiac muscleHuman physiologyEndocrinologymedicine.anatomical_structurePhysiology (medical)Internal medicinemedicineTheophyllineReceptorRat atriamedicine.drugIonotropic effectdescription
It is concluded that the positive inotropic action of DB-AMP—at least in isolated rat atria—may resemble that of adrenaline or theophylline in some points, e.g. with regard to its dependence on the [Ca]e. But as no positive inotropic effect could be observed in guinea-pig atria and as the mechanism by which DB-AMP augments contractile force remains obscure, the results are not thought to necessarily support the view that the effects of adrenaline or theophylline on contractile behaviour of mammalian cardiac muscle occur via cyclic AMP.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1972-01-01 | Pfl�gers Archiv European Journal of Physiology |