6533b837fe1ef96bd12a1d85
RESEARCH PRODUCT
Reference standard space hippocampus labels according to the European Alzheimer's Disease Consortium–Alzheimer's Disease Neuroimaging Initiative harmonized protocol: Utility in automated volumetry
Dominik WolfMartina BocchettaGregory M PreboskeMarina BoccardiMichel J. GrotheAlzheimer's Disease Neuroimaging Initiativesubject
Magnetic Resonance Imaging/methods/standardsMaleJaccard indexEpidemiologyComputer sciencemethods [Pattern Recognition Automated]Image ProcessingAutomated/methods/standardsHippocampusPattern Recognition Automatedddc:616.89methods [Magnetic Resonance Imaging]0302 clinical medicinemethods [Image Processing Computer-Assisted]Image Processing Computer-AssistedComputer-Assisted/methods/standardsHARPdiagnostic imaging [Hippocampus]Health Policy05 social sciencesOrgan SizeReference StandardsMagnetic Resonance ImagingHippocampal segmentationstandards [Image Processing Computer-Assisted]Psychiatry and Mental healthNeuroimaging/methods/standardsFemalemethods [Neuroimaging]Hippocampus/diagnostic imagingAlzheimer's Disease Neuroimaging InitiativeAlzheimer Disease/diagnostic imagingNeuroimagingPattern Recognition050105 experimental psychology03 medical and health sciencesCellular and Molecular NeuroscienceDevelopmental NeuroscienceNeuroimagingAlzheimer DiseaseHumans0501 psychology and cognitive sciencesddc:610Reference standardsAgedProtocol (science)standards [Magnetic Resonance Imaging]business.industryPattern recognitionGold standard (test)Neurology (clinical)Artificial intelligenceGeriatrics and Gerontologybusinessdiagnostic imaging [Alzheimer Disease]standards [Pattern Recognition Automated]Neurosciencestandards [Neuroimaging]030217 neurology & neurosurgerydescription
Abstract Introduction A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium–Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. Methods Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels. Utility and validity of these reference labels is demonstrated in a simple atlas-based morphometry approach for automated calculation of HarP-compliant hippocampal volumes within SPM software. Results Individual tracings showed very high agreement among the four expert tracers (pairwise Jaccard indices 0.82–0.87). Automatically calculated hippocampal volumes were highly correlated (rL/R = 0.89/0.91) with gold standard volumes in the HarP benchmark data set (N = 135 MRIs), with a mean volume difference of 9% (standard deviation 7%). Conclusion The consensual HarP hippocampus labels in the MNI152 template can serve as a reference standard for automated image analyses involving MNI standard space normalization.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 | Alzheimer's & Dementia |