6533b837fe1ef96bd12a1e0f
RESEARCH PRODUCT
Asymmetric Allylation/RCM-Mediated Synthesis of Fluorinated Benzo-Fused Bicyclic Homoallylic Amines As Dihydronaphthalene Derivatives
Raquel RománSantos FusteroDaniel M. SedgwickPablo BarrioAntonio Simónsubject
Ring-closing metathesisBicyclic molecule010405 organic chemistryStereochemistryChemistryOrganic Chemistry010402 general chemistry01 natural sciencesMedicinal chemistry0104 chemical sciencesdescription
Enantiomerically enriched fluorinated benzo-fused bicyclic homoallylic amities have been synthesized through an asymmetric allylation/ring closing metathesis (RCM) sequence. This sequence has been carried out using alpha-trifluoromethylstyrene derivatives as key intermediates, synthesized by microwave radiation. The great deactivating effect exerted by such substituents has been brought to light by a comparative study.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |