6533b837fe1ef96bd12a1f12
RESEARCH PRODUCT
How Can We Improve the Vaccination Response in Older People? Part II: Targeting Immunosenescence of Adaptive Immunity Cells.
Maider GarnicaAnna AielloMattia Emanuela LigottiGiulia AccardiHugo ArasanzAna BocanegraEster BlancoAnna CalabròLuisa ChocarroMiriam EchaideGrazyna KochanLeticia Fernandez-rubioPablo RamosFanny PojeroNahid ZareianSergio Piñeiro-hermidaFarzin FarzanehGiuseppina CandoreCalogero CarusoDavid Escorssubject
Settore MED/04 - Patologia GeneraleB cellAgingImmunosenescenceOrganic ChemistryVaccinationT cellGeneral MedicinevaccinesAdaptive ImmunityCatalysisComputer Science ApplicationsInorganic ChemistryQuality of LifeHumansPhysical and Theoretical ChemistryMolecular BiologySpectroscopyAgeddescription
The number of people that are 65 years old or older has been increasing due to the improvement in medicine and public health. However, this trend is not accompanied by an increase in quality of life, and this population is vulnerable to most illnesses, especially to infectious diseases. Vaccination is the best strategy to prevent this fact, but older people present a less efficient response, as their immune system is weaker due mainly to a phenomenon known as immunosenescence. The adaptive immune system is constituted by two types of lymphocytes, T and B cells, and the function and fitness of these cell populations are affected during ageing. Here, we review the impact of ageing on T and B cells and discuss the approaches that have been described or proposed to modulate and reverse the decline of the ageing adaptive immune system.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-08-29 | International journal of molecular sciences |