MEP metaboliskā ceļa matemātiskā modeļa izveide izoprēna un cis-abienola ražošanai Tāla sīkplikstiņā

6533b837fe1ef96bd12a2212

RESEARCH PRODUCT

MEP metaboliskā ceļa matemātiskā modeļa izveide izoprēna un cis-abienola ražošanai Tāla sīkplikstiņā

Katrīna Daila Neiburga

subject

izoprēna biosintēze kinētiskā modelēšana MEP metaboliskais ceļš cis-abienola biosintēze tāla sīkplikstiņš Bioloģija

description

Darbā apskatīta sistēmbioloģijas pieeja augu biotehnoloģijai, tās nozīme un priekšrocības eksperimentālo un modelēšanas metožu apvienošanai. Šī darba ietvaros izveidots matemātiskais modelis MEP metaboliskā ceļa un izoprenoīdu prekursoru sintēzes kinētikai tāla sīkplikstiņa savvaļas formā ar tālāko mērķi to izmantot izoprēna un cis-abienola biosintēzes ceļu optimizācijai. Darba ietvaros tika veikta parametru novērtēšana, stacionārā stāvokļa noteikšana un parametru jutības analīze, pielāgojot modeļa darbību eksperimentālajiem datiem. Darba ietvaros izmēģinātas iespējas samazināt parametru novērtēšanas risinājumu telpu, aprēķinot bioloģiski atbilstošas robežvērtības un genoma mēroga stehiometriskās modelēšanas datu iekļaušana kinētiskajā modelī stacionārā stāvoklī.

year	journal	country	edition	language
2018-01-01

https://dspace.lu.lv/dspace/handle/7/39624

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