Ligand-receptor interactions directly measured with the surface forces apparatus

6533b837fe1ef96bd12a2638

RESEARCH PRODUCT

Ligand-receptor interactions directly measured with the surface forces apparatus

Wolfgang Knoll Christiane A. Helm Christiane A. Helm Christiane A. Helm Jacob N. Israelachvili Franz-josef Schmitt

subject

Streptavidin chemistry.chemical_compound Crystallography Polymers and Plastics chemistry Biotin Ligand Organic Chemistry Materials Chemistry Surface forces apparatus Condensed Matter Physics Receptor Binding force

description

Ligand-receptor interactions give rise to very strong bonds due to perfect geometrical fit. Using the Surface Forces Apparatus we have studied the interactions between membrane-bound biotin ligands and streptavidin receptors. We find an unusually strong short-range binding force associated with equally specific molecular rearrangements-both qualitatively and quantitatively unlike anything previously measured.

year	journal	country	edition	language
1991-06-01	Makromolekulare Chemie. Macromolecular Symposia

https://doi.org/10.1002/masy.19910460114

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