6533b837fe1ef96bd12a2796

RESEARCH PRODUCT

Integrative proteomics: functional and molecular characterization of a particular glutamate-related neuregulin isoform.

Simone SchilloWerner J. SchmidtVojislav PejovicTorsten HansenAndré SchrattenholzSlobodan PoznanovićChristian HunzingerJörg Kriegsmann

subject

ProteomicsNeuregulin-1Glutamic AcidNerve Tissue ProteinsBiochemistryHippocampusRats Sprague-DawleyAlzheimer DiseaseAnimalsHumansLearningProtein IsoformsNeuregulin 1ReceptorLipid raftCells CulturedbiologyGlutamate receptorGeneral ChemistryGlutamic acidCell biologyRatsbiology.proteinNeuregulinCalciumFemaleSynaptic signalingSignal transductionBiomarkersSignal Transduction

description

Glutamate is the major excitatory neurotransmitter in the mammalian brain and is related to memory by calcium-conducting receptors. Neuregulins have emerged as long-term modulating molecules of synaptic signaling by glutamate receptors, playing a role in some cognition/memory-related disorders and moreover being part of transient functional microdomains, called lipid rafts. Here we characterize one specific isoform of neuregulin as a central biomarker for glutamate-related signaling, integrating results from in vitro and in vivo models by a differential functional and proteomic approach.

yearjournalcountryeditionlanguage
2005-03-29Journal of proteome research
10.1021/pr050012phttps://pubmed.ncbi.nlm.nih.gov/15952737