Microstructural assessment of rodent behavior in the hole-board experimental assay

6533b837fe1ef96bd12a28a8

RESEARCH PRODUCT

Microstructural assessment of rodent behavior in the hole-board experimental assay

Andrea Santangelo Giuseppe Crescimanno Filippina Sorbera Maurizio Casarrubea

subject

body regions Multivariate statistics Multivariate analysis Multivariate analysis stochastic analysis hole-board rat.medicine Anxiety Multivariate analysis stochastic analysis hole-board rat medicine.symptom Psychology Settore BIO/09 - Fisiologia Developmental psychology

description

The aim of the present methodological article was to assess whether a microstructure of hole-exploratory activity can be demonstrated in rats tested in the hole-board, an experimental assay widely used to study anxiety-related behaviors in rodents. Six never properly described hole exploratory behavioral components were identified: active-dip, static-dip, rapid-dip, circular-sniff, point-sniff and central-sniff. Results, assessed by means of descriptive and multivariate approaches, reveal a complex microstructural organization of these behavioral elements. The hypothesis of an important role of the relationships between point-sniff and head dipping activities, in anxiety-related hole exploratory behavior, is proposed. It is suggested that the microstructural analysis can evidence even subtle behavioral changes induced by manipulations of animal anxiety condition.

year	journal	country	edition	language
2010-08-24	Proceedings of the 7th International Conference on Methods and Techniques in Behavioral Research

https://doi.org/10.1145/1931344.1931361

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