6533b837fe1ef96bd12a298b
RESEARCH PRODUCT
Age- and training-related changes in the collagen metabolism of rat skeletal muscle
Harri SuominenVuokko Kovanensubject
MaleAgingmedicine.medical_specialtyPhysiologyProcollagen-Proline DioxygenaseConnective tissueRectus femoris muscleBiologyEndurance trainingPhysical Conditioning AnimalPhysiology (medical)Internal medicinemedicineAnimalsOrthopedics and Sports MedicineSoleus muscleMusclesPublic Health Environmental and Occupational HealthSkeletal muscleRats Inbred StrainsGeneral MedicineEnzyme assayRatsmedicine.anatomical_structureEndocrinologyGlucosyltransferasesAgeingbiology.proteinCollagenType I collagendescription
The effects of ageing and life-long endurance training on the collagen metabolism of skeletal muscle were evaluated in a longitudinal study. Wistar rats performed treadmill running 5 days a week for 2 years. The activities of collagen biosynthesis enzymes, prolyl-4-hydroxylase and galactosylhydroxylysyl glucosyltransferase, were highest in the muscles of the youngest animals, decreased up to the age of 2 months and from then on remained virtually unchanged. The enzyme activity in young animals was higher in the slow collagenous soleus muscle than in the rectus femoris muscle. The enzyme activity in the soleus muscle was higher for older trained rats than older untrained rats. The relative proportion of type I collagen increased and that of type III collagen decreased with age, suggesting a more marked contribution by type I collagen to the age-related accumulation of total muscular collagen. The results show that collagen biosynthesis decreases with maturation and that life-long endurance training maintains a higher level of biosynthesis in slow muscles.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-01-01 | European Journal of Applied Physiology and Occupational Physiology |