6533b837fe1ef96bd12a31e4
RESEARCH PRODUCT
Organocatalytic Enantioselective Friedel-Crafts Alkylation of 1-Naphthol Derivatives and Activated Phenols with Ethyl Trifluoropyruvate
Carlos VilaGonzalo BlayIsabel FernándezJosé R. PedroMarc Montesinos-magranerM. Carmen Muñozsubject
biologyOrganocatalysis1-NaphtholEnantioselective synthesisGeneral ChemistryNaphtholsbiology.organism_classificationTrifluoropyruvatesReaccions químiqueschemistry.chemical_compoundEthyl trifluoropyruvatechemistryCatàlisiOrganocatalysisFISICA APLICADAAsymmetric catalysisOrganic chemistryPhenolsValenciaFriedel–Crafts reactionQuímica orgànicaFriedel–Crafts reactiondescription
An organocatalytic enantioselective Friedel–Crafts alkylation of a series of substituted 1- naphthol derivatives and activated phenols with ethyl trifluoropyruvate, catalyzed by a quinine-derived squaramide, is presented. Good yields and high to excellent enantioselectivities of the Friedel– Crafts alkylation products were obtained.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |