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RESEARCH PRODUCT
Are there dynamical effects in enzyme catalysis? Some thoughts concerning the enzymatic chemical step.
Iñaki TuñónJames T. HynesJames T. HynesDamien Laagesubject
StereochemistryProtein ConformationBiophysicsBiochemistryModels BiologicalVibrationArticleEnzyme catalysisDiffusionTransition state theoryTransition State TheoryEscherichia coli[CHIM]Chemical SciencesStatistical physicsMolecular BiologyQuantumNuclear motionChemistryQuantitative Biology::Molecular Networksdigestive oral and skin physiologyEnzyme catalysisEnzymesEnzyme ActivationKineticsTetrahydrofolate DehydrogenaseDynamical effectsBiocatalysisQuantum TheoryTetrahydrofolate dehydrogenaseProtonsdescription
Highlights • The possible role of enzymatic reaction dynamical effects is examined. • Solution reactions usefully inform the issue of dynamical effects in enzymes. • Division into regions containing and away from the transition state is important. • Motions in passage to/from the transition state need not lead to dynamical effects. • Transition State Theory is usually a reasonable description of enzyme kinetics.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-09-15 | Archives of biochemistry and biophysics |