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RESEARCH PRODUCT
Calcium Polyphosphate Nanoparticles Act as an Effective Inorganic Phosphate Source during Osteogenic Differentiation of Human Mesenchymal Stem Cells
Keith ThompsonMartin J. StoddartWerner E. G. M�llerLuan Phelipe HattAngela R. Armientosubject
0301 basic medicineCalcium PhosphatesCellCell Culture Techniques02 engineering and technologyExtracellular matrixlcsh:Chemistrychemistry.chemical_compoundOsteogenesisPolyphosphateslcsh:QH301-705.5SpectroscopyCells CulturedCell DifferentiationGeneral Medicine021001 nanoscience & nanotechnologyComputer Science ApplicationsCell biologymedicine.anatomical_structureGlycerophosphatesAlkaline phosphatase0210 nano-technologyinorganic polyphosphateStromal cellchemistry.chemical_elementosteogenic differentiationCalciumCatalysisArticleInorganic Chemistry03 medical and health sciencesmedicineHumansPhysical and Theoretical ChemistryMolecular Biologymesenchymal stem cellsPolyphosphateOrganic ChemistryMesenchymal stem cellβ-glycerolphosphateCa-polyphosphate nanoparticlesPhosphateAlkaline Phosphatase030104 developmental biologychemistrylcsh:Biology (General)lcsh:QD1-999Gene Expression RegulationNanoparticlesCalciumdescription
The ability of bone-marrow-derived mesenchymal stem/stromal cells (BM-MSCs) to differentiate into osteoblasts makes them the ideal candidate for cell-based therapies targeting bone-diseases. Polyphosphate (polyP) is increasingly being studied as a potential inorganic source of phosphate for extracellular matrix mineralisation. The aim of this study is to investigate whether polyP can effectively be used as a phosphate source during the in vitro osteogenic differentiation of human BM-MSCs. Human BM-MSCs are cultivated under osteogenic conditions for 28 days with phosphate provided in the form of organic &beta
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-11-18 | International Journal of Molecular Sciences |