Preliminary approach towards construction of peptide libraries as potential tools for diagnosis of malignant thyroid tumors

6533b838fe1ef96bd12a3f6e

RESEARCH PRODUCT

Preliminary approach towards construction of peptide libraries as potential tools for diagnosis of malignant thyroid tumors

subject

neoplasma folliculare thyroid gland gruczolak pęcherzykowy papillary thyroid cancer rak brodawkowaty rak rdzeniasty system diagnostyczny medullary thyroid cancer tarczyca diagnostic tool

description

Nowotwory złośliwe tarczycy należą do najczęstszych nowotworów złośliwych układu endokrynnego. Poprawa wyników leczenia wiąże się z postępem wczesnej diagnostyki raka. Celem niniejszych badań jest poszukiwanie wskaźników nowotworowych za pomocą bibliotek peptydowych umieszczonych na podłożu z bibuły. Materiał i metody: Analizie poddano tkanki pobrane od 6 pacjentów: 4 z rakiem brodawkowatym tarczycy, 1 z nowotworem pęcherzykowym oraz 1 pacjenta z rakiem oksyfilnym. Badania wykonywano z wykorzystaniem bibliotek peptydowych lipofilowych, porównując tkankę zdrową i chorą oraz oceniając zmianę zabarwienia w poszczególnych bibliotekach. Wyniki: Wstępne wyniki wskazują, że biblioteki peptydowe można zastosować w diagnostyce nowotworów tarczycy. Wnioski: Niezbędna jest optymalizacja budowy bibliotek peptydowych, gdzie konieczne jest zastosowanie innego barwnika hydrolizowanego przez proteazy.

year	journal	country	edition	language
2006-01-01	Endokrynologia Polska (Polish Journal of Endocrinology)

https://journals.viamedica.pl/endokrynologia_polska/article/view/25708/20530

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