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RESEARCH PRODUCT

Instability of Tandem Repetitive DNA in “Natural” and Transgenic Organisms

Andreas WinterpachtErwin R. SchmidtThomas Hankeln

subject

GeneticsBiologyPosition-effect variegationDNA sequencingGermlineGenetically modified organismTransgenesischemistry.chemical_compoundmedicine.anatomical_structurechemistrymedicineSomaRepeated sequenceDNA

description

Genome research of the last 10 years has forced us to re-evaluate our view of DNA as a relatively stable molecule. Unprecedented levels of DNA instability in germline and soma cells have been observed, associated primarily with tandem repetitive (tr) DNA sequences. We will discuss here briefly the structure and possible functions of trDNA in eukaryotes, the putative mechanisms of mutational change in repeat clusters and the evolutionary dimensions of trDNA instability (for other relevant reviews, sec Pardue and Hennig 1990; Vogt 1990; Charlesworth et al. 1994). A special focus will be on the behaviour of trDNA after DNA transfer experiments in transgenic organisms, with reference to our own work in dipteran insects.

yearjournalcountryeditionlanguage
1996-01-01
https://doi.org/10.1007/978-3-642-61460-6_19