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RESEARCH PRODUCT

“Brainstorming”: Extracellular Vesicles in Physical Activity and Neuronal Health

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description

Physical and mental activity are known to contribute to brain health and overall longevity. Extracellular vesicles (EVs) have attracted attention for their ability to transport bioactive cargo through various body-fluids and their role in tissue crosstalk and regeneration. Targeted intercellular communication processes, including those facilitated by EVs, are of vital importance for the complex architecture and function of the brain. Activated neurons trigger the transfer of EVs from myelinating oligodendrocytes to neurons, promoting neuronal long-term maintenance and survival. Likewise, physical activity leads to the liberation of EVs into the circulation, while the molecular link between physical activity and neural performance is not yet fully understood. Interestingly, there are indications that EVs might be able to overcome the blood-brain-barrier and affect neuronal cells. Here, we discuss the ability of EVs to “storm the brain” in response to neural and physical activity in benefit of well-being and sustained brain health. Keywords: oligodendrocytes, neuron-glia interaction, extracellular vesicles, physical exercise, neuronal maintenance, neuroprotection